CARD8 antibody

Catalog No. ABIN5963070

The Rabbit Polyclonal anti-CARD8 antibody is suitable to detect CARD8 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for CARD8 antibody (ABIN5963070)

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CARD8 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human CARD8

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Alternative Name: CARD8

Background:

Synonyms: Apoptotic protein NDPP 1,Apoptotic protein NDPP1,CARD 8,CARD inhibitor of NF kappa B activating ligand,CARD inhibitor of NF kappaB activating ligand,CARD inhibitor of NF kappaB activating ligands,CARD-inhibitor of NF-kappa-B-activating ligand,CARD8,CARD8,CARDINAL,Caspase recruitment domain containing protein 8,Caspase recruitment domain family member 8,Caspase recruitment domain protein 8,Caspase recruitment domain-containing protein 8,DACAR,Dakar,DKFZp779L0366,FLJ18119,FLJ18121,KIAA0955,MGC57162,NDPP 1,NDPP,NDPP1,TUCAN,Tumor up regulated CARD containing antagonist of CASP9,Tumor up regulated CARD containing antagonist of caspase 9,Tumor up-regulated CARD-containing antagonist of CASP9,tumor up-regulated CARD-containing antagonist of caspase nine,Tumor upregulated CARD containing antagonist of CASP9

Background: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.

Molecular Weight:

Observed_MW: 55kDa

Calculated_MW: 32kDa/44kDa/48kDa/55kDa/60kDa

Gene ID: 22900

UniProt: Q9Y2G2

Pathways: Positive Regulation of Endopeptidase Activity