NUMA1 antibody

Catalog No. ABIN6566605

This Rabbit Polyclonal antibody specifically detects NUMA1 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NUMA1 antibody (ABIN6566605)

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NUMA1 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human NUMA1

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:1000 IHC 1:50 - 1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NUMA1

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Alternative Name: NUMA1

Background:

Synonyms: Centrophilin stabilizes mitotic spindle in mitotic cells,NMP 22,Nuclear matrix protein 22,Nuclear mitotic apparatus protein 1,Nuclear mitotic apparatus protein,NUMA 1,NUMA,NuMA protein,NUMA1,NUMA1,SP H antigen,SP-H antigen,Structural nuclear protein

Background: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 238kDa

Calculated_MW: 109kDa/200kDa/201kDa/236kDa/238kDa

Gene ID: 4926

UniProt: Q14980

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase