PKN1 antibody

Catalog No. ABIN6566611

This Rabbit Polyclonal antibody specifically detects PKN1 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PKN1 antibody (ABIN6566611)

Target: PKN1 (Protein Kinase N1 (PKN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PKN1 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human PKN1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:1000 IHC 1:50 - 1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PKN1

Target: PKN1 (Protein Kinase N1 (PKN1))

Alternative Name: PKN1

Background:

Synonyms: DBK,DPKN,PAK 1,PRK 1,PROTEIN KINASE C RELATED KINASE 1,SERINE/THREONINE PROTEIN KINASE N

Background: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Molecular Weight:

Observed_MW: 120kDa

Calculated_MW: 104kDa

Gene ID: 5585

UniProt: Q16512