Desmocollin 1 antibody

Catalog No. ABIN6566762

The Rabbit Polyclonal anti-Desmocollin 1 antibody has been validated for WB. It is suitable to detect Desmocollin 1 in samples from Human, Mouse and Rat.

Quick Overview for Desmocollin 1 antibody (ABIN6566762)

Target: Desmocollin 1 (DSC1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Desmocollin 1 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human DSC1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Desmocollin 1

Target: Desmocollin 1 (DSC1)

Alternative Name: DSC1

Background:

Synonyms: Cadherin family member 1,CDHF1,Desmocollin1,Desmosomal glycoprotein 2/3,DG2/DG3,DSC 1,DSC1

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.

Molecular Weight:

Observed_MW: 105kDa

Calculated_MW: 93kDa/99kDa

Gene ID: 1823

UniProt: Q08554