PAX5 antibody

Catalog No. ABIN6567312

This Rabbit Polyclonal antibody specifically detects PAX5 in WB. It exhibits reactivity toward Human and Rat.

Quick Overview for PAX5 antibody (ABIN6567312)

Target: PAX5 (Paired Box 5 (PAX5))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAX5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PAX5 Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human PAX5

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PAX5

Target: PAX5 (Paired Box 5 (PAX5))

Alternative Name: PAX5

Background:

Synonyms: B cell lineage specific activator,B cell lineage specific activator protein,B cell specific activator protein,B cell specific transcription factor,B-cell-specific transcription factor,BSAP,EBB-1,KLP,Paired box 5,Paired box gene 5 (B cell lineage specific activator protein),Paired box gene 5 (B cell lineage specific activator),Paired box gene 5,Paired box homeotic gene 5,Paired box protein Pax 5,Paired box protein Pax-5,Paired domain gene 5,PAX 5,PAX5,PAX5,Transcription factor PAX 5

Background: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight:

Observed_MW: 42kDa

Calculated_MW: 31kDa/32kDa/34kDa/35kDa/37kDa/38kDa/42kDa

Gene ID: 5079

UniProt: Q02548