GCN2 antibody

Catalog No. ABIN6567595

This Rabbit Polyclonal antibody specifically detects GCN2 in WB, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GCN2 antibody (ABIN6567595)

Target: GCN2 (EIF2AK4) (Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GCN2 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human EIF2AK4

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GCN2

Target: GCN2 (EIF2AK4) (Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))

Alternative Name: EIF2AK4

Background:

Synonyms: E2AK4,Eif2ak4,Eukaryotic Translation Initiation Factor 2 alpha kinase 4,Eukaryotic translation initiation factor 2-alpha kinase 4,GCN2,GCN2 eIF2alpha kinase,GCN2 like protein,GCN2-like protein,KIAA1338,MGCN2

Background: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.

Molecular Weight:

Observed_MW: 187kDa

Calculated_MW: 69kDa/183kDa/186kDa

Gene ID: 440275

UniProt: Q9P2K8

Pathways: ER-Nucleus Signaling, Hepatitis C