Coagulation Factor X antibody

Catalog No. ABIN6568380

This anti-Coagulation Factor X antibody is a Rabbit Polyclonal antibody detecting Coagulation Factor X in IF. Suitable for Human and Mouse.

Quick Overview for Coagulation Factor X antibody (ABIN6568380)

Target: Coagulation Factor X (F10)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Coagulation Factor X antibody is un-conjugated

Application: Immunofluorescence (IF)

Product Details anti-Coagulation Factor X Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human F10 (NP_000495.1).

Isotype: IgG

Application Details

Application Notes: IF 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Coagulation Factor X

Target: Coagulation Factor X (F10)

Alternative Name: F10

Background: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds, the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Molecular Weight:

Observed_MW: 75kDa

Calculated_MW: 54kDa

Gene ID: 2159

UniProt: P00742