EBP antibody

Catalog No. ABIN6568497

This Rabbit Polyclonal antibody specifically detects EBP in WB. It exhibits reactivity toward Mouse and Rat.

Quick Overview for EBP antibody (ABIN6568497)

Target: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EBP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EBP Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human EBP

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EBP

Target: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Alternative Name: EBP

Background:

Synonyms: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase,CDPX2 ,CHO2,Cholestenol Delta-isomerase,CPX,CPXD,D8-D7 sterol isomerase,Delta(8)-Delta(7) sterol isomerase,ebp,EBP,Emopamil-binding protein,Msi

Background: The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23 % ) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).

Molecular Weight:

Observed_MW: 26kDa

Calculated_MW: 26kDa

Gene ID: 10682

UniProt: Q15125