C9ORF72 antibody (C-Term)

Catalog No. ABIN656852

The Rabbit Polyclonal anti-C9ORF72 antibody has been validated for WB. It is suitable to detect C9ORF72 in samples from Human. There are 3+ publications available.

Quick Overview for C9ORF72 antibody (C-Term) (ABIN656852)

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C9ORF72 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB27382

Product Details anti-C9ORF72 Antibody

Binding Specificity: AA 396-424, C-Term

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This C9orf72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-424 amino acids from the C-terminal region of human C9orf72.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: C9orf72 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-C9ORF72 antibody (ABIN656852)

Davidson, Robinson, Rollinson, Pickering-Brown, Xiao, Robertson, Mann: "Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies." in: Amyotrophic lateral sclerosis & frontotemporal degeneration, Vol. 19, Issue 1-2, pp. 102-111, (2018) (PubMed).

Sullivan, Zhou, Robins, Paushter, Kim, Smolka, Hu: "The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway." in: Acta neuropathologica communications, Vol. 4, Issue 1, pp. 51, (2017) (PubMed).

Burberry, Suzuki, Wang, Moccia, Mordes, Stewart, Suzuki-Uematsu, Ghosh, Singh, Merkle, Koszka, Li, Zon, Rossi, Trowbridge, Notarangelo, Eggan: "Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease." in: Science translational medicine, Vol. 8, Issue 347, pp. 347ra93, (2017) (PubMed).

Target Details for C9ORF72

Target: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Alternative Name: C9orf72

Molecular Weight: 54328

Gene ID: 203228

NCBI Accession: NP_001242983, NP_060795, NP_659442

UniProt: Q96LT7