SMPD4 antibody

Catalog No. ABIN6568719

This anti-SMPD4 antibody is a Rabbit Polyclonal antibody detecting SMPD4 in WB. Suitable for Human and Mouse.

Quick Overview for SMPD4 antibody (ABIN6568719)

Target: SMPD4 (Sphingomyelin Phosphodiesterase 4 (SMPD4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMPD4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMPD4 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human SMPD4

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SMPD4

Target: SMPD4 (Sphingomyelin Phosphodiesterase 4 (SMPD4))

Alternative Name: SMPD4

Background:

Synonyms: EC 3.1.4.12,EC=3.1.4.123,FLJ20297,FLJ20756,KIAA1418,NET 13,NET13,Neutral sphingomyelinase 3,Neutral sphingomyelinase III,NSMA3,nSMase 3,nSMase-3,nSMase3,OTTHUMP00000162391,OTTHUMP00000190862,SKNY protein,smpd4,Sphingomyelin phosphodiesterase 4,Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase 3)

Background: The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network.

Molecular Weight:

Observed_MW: 100kDa

Calculated_MW: 44kDa, 56-69kDa, 83-98kDa

Gene ID: 55627

UniProt: Q9NXE4