LRWD1 antibody

Catalog No. ABIN6568759

This Rabbit Polyclonal antibody specifically detects LRWD1 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LRWD1 antibody (ABIN6568759)

Target: LRWD1 (Leucine-Rich Repeat and WD Repeat-Containing Protein 1 (LRWD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRWD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LRWD1 Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human Lrwd1

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LRWD1

Target: LRWD1 (Leucine-Rich Repeat and WD Repeat-Containing Protein 1 (LRWD1))

Alternative Name: Lrwd1

Background:

Synonyms: 1200011O22Rik,AU042569,AW548074,DKFZp434K1815,Leucine rich repeats and WD repeat domain containing 1,Leucine-rich repeat and WD repeat-containing protein 1,LRWD1,LRWD1,ORC-associated protein,ORCA,Origin recognition complex-associated protein

Background: The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 65kDa

Calculated_MW: 70kDa

Gene ID: 222229

UniProt: Q9UFC0

Pathways: Chromatin Binding