IRAK4 antibody

Catalog No. ABIN6570285

The Rabbit Polyclonal anti-IRAK4 antibody has been validated for WB and IHC. It is suitable to detect IRAK4 in samples from Human, Mouse and Rat.

Quick Overview for IRAK4 antibody (ABIN6570285)

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-IRAK4 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human IRAK4

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IRAK4

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Alternative Name: IRAK4

Background:

Synonyms: IL-1 receptor-associated kinase 4,Interleukin 1 receptor associated kinase 4 mutant form 1,Interleukin-1 receptor-associated kinase 4,Interleukin1 receptor associated kinase 4,IPD1,IRAK 4,IRAK-4,IRAK4,IRAK4 mutated form 1,IRAK4,LOC 51135,NY REN 64,NY REN 64 antigen,NY-REN-64,REN64,Renal carcinoma antigen NY-REN-64

Background: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 55kDa

Calculated_MW: 37kDa/51kDa

Gene ID: 51135

UniProt: Q9NWZ3

Pathways: NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades