WISP2 antibody

Catalog No. ABIN6571151

This Rabbit Polyclonal antibody specifically detects WISP2 in WB. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for WISP2 antibody (ABIN6571151)

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WISP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WISP2 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human WISP2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for WISP2

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Alternative Name: WISP2

Background:

Synonyms: CCN family member 5,CCN5,Connective tissue growth factor like protein,Connective tissue growth factor related protein 58,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGF L,CTGF-L,WISP 2,WISP-2,Wisp2,WISP2,Wnt 1 signaling pathway protein 2,WNT1 inducible signaling pathway protein 2,WNT1-inducible-signaling pathway protein 2

Background: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Molecular Weight:

Observed_MW: 27kDa

Calculated_MW: 22kDa/26kDa

Gene ID: 8839

UniProt: O76076

Pathways: WNT Signaling, Growth Factor Binding