SPR antibody

Catalog No. ABIN6571463

The Rabbit Polyclonal anti-SPR antibody is suitable to detect SPR in samples from Human, Mouse, Rat and Monkey. It has been validated for WB and IHC.

Quick Overview for SPR antibody (ABIN6571463)

Target: SPR (Sepiapterin Reductase (SPR))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SPR Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human SPR

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IHC 1:50 - 1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPR

Target: SPR (Sepiapterin Reductase (SPR))

Alternative Name: SPR

Background:

Synonyms: OTTHUMP00000160199,SDR38C1,Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase),Sepiapterin reductase,Short chain dehydrogenase/reductase family 38C,member 1,SPR,SPRE

Background: This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.

Molecular Weight:

Observed_MW: 28kDa

Calculated_MW: 28kDa

Gene ID: 6697

UniProt: P35270

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration