SART1 antibody

Catalog No. ABIN6571846

This anti-SART1 antibody is a Rabbit Polyclonal antibody detecting SART1 in WB and IP. Suitable for Human, Mouse and Rat.

Quick Overview for SART1 antibody (ABIN6571846)

Target: SART1 (Squamous Cell Carcinoma Antigen Recognized By T Cells (SART1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SART1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-SART1 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human SART1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IP 1:20 - 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SART1

Target: SART1 (Squamous Cell Carcinoma Antigen Recognized By T Cells (SART1))

Alternative Name: SART1

Background:

Synonyms: Ara 1,ARA1,HOMS 1,HOMS1,hSART 1,hSART1,hSnu 66,hSnu66,IgE autoantigen,MGC2038,SART 1,SART1 259,SART1(259) protein,SART1(800) protein,SART1259,Snu 66,Snu66 ,Squamous cell carcinoma antigen recognised by T cells,Squamous cell carcinoma antigen recognized by T cells 1,U4/U6.U5 tri snRNP associated 110 kDa protein ,U4/U6.U5 tri snRNP associated protein 1

Background: This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation, its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Molecular Weight:

Observed_MW: 120kDa

Calculated_MW: 90kDa

Gene ID: 9092

UniProt: O43290

Pathways: Ribonucleoprotein Complex Subunit Organization