CD44 antibody

Catalog No. ABIN2843760

The Mouse Monoclonal anti-CD44 antibody has been validated for FACS, WB, IF and IHC (p). It is suitable to detect CD44 in samples from Human. There are 2+ publications available.

Quick Overview for CD44 antibody (ABIN2843760)

Target: CD44

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD44 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: Hermes-3

Product Details anti-CD44 Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This CD44 monoclonal antibody is against human Peyer's patch endothelial cells (CD44) .

Isotype: IgG2a kappa

Application Details

Application Notes: IF: 1:10~50. WB: 1:2000. IHC-P: 1:10~50. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CD44 antibody (ABIN2843760)

Yan, Li, Xu, Chen, Wei, Fan, Chen, Li, Wang, Huang: "All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy." in: BMC complementary and alternative medicine, Vol. 16, pp. 113, (2016) (PubMed).

Wu, Bluguermann, Kyupelyan, Latour, Gonzalez, Shah, Galic, Ge, Zhu, Petrigliano, Nsair, Miriuka, Li, Lyons, Crooks, McAllister, Van Handel, Adams, Evseenko: "Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells." in: Stem cell reports, Vol. 1, Issue 6, pp. 575-89, (2015) (PubMed).

Target Details for CD44

Target: CD44

Alternative Name: CD44

Background: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

Molecular Weight: 81538

Gene ID: 960

NCBI Accession: NP_000601, NP_001001389, NP_001001390, NP_001001391, NP_001001392, NP_001189484, NP_001189485, NP_001189486

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling