HAVCR1 antibody (AA 58-289)

Catalog No. ABIN6654049

The Rabbit Polyclonal anti-HAVCR1 antibody has been validated for WB and ELISA (Capture). It is suitable to detect HAVCR1 in samples from Human.

Quick Overview for HAVCR1 antibody (AA 58-289) (ABIN6654049)

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAVCR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA (Capture)

Product Details anti-HAVCR1 Antibody

Binding Specificity: AA 58-289

Purification: Antigen affinity purified

Immunogen: Amino acids Q58-K289 from the human protein were used as the immunogen for the TIM1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TIM1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,ELISA (Capture): 1-5 μg/mL (human recombinant protein)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the TIM1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for HAVCR1

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Alternative Name: KIM-1 / TIM-1 / HAVCR1

Target Type: Virus

Background: KIM1 (KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that TIM1 is capable of homophilic Tim-Tim interactions. The protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, TIM1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of TIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. TIM1-expressing epithelial cells internalized apoptotic bodies, and the protein is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.

UniProt: Q96D42