XPO1 antibody (AA 966-1071)

Catalog No. ABIN6654156

This Mouse Monoclonal antibody specifically detects XPO1 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for XPO1 antibody (AA 966-1071) (ABIN6654156)

Target: XPO1 (Exportin 1 (XPO1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This XPO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 5G3

Product Details anti-XPO1 Antibody

Binding Specificity: AA 966-1071

Purification: Protein G affinity

Immunogen: Human Exportin-1 recombinant protein (amino acids N966-D1071) was used as the immunogen for the XPO1 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the XPO1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the XPO1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for XPO1

Target: XPO1 (Exportin 1 (XPO1))

Alternative Name: XPO1

Background: Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), is an eukaryotic protein that mapped to human chromosome 2p16 by fluorescence in situ hybridization. This protein mediates leucine-rich nuclear export signal (NES)-dependent protein transport. It specifically inhibits the nuclear export of Rev and U snRNAs. Additionally, this protein is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. It also regulates NFAT and AP-1.

UniProt: O14980

Pathways: M Phase