CCL8 antibody (AA 24-97)

Catalog No. ABIN6654185

This anti-CCL8 antibody is a Rabbit Polyclonal antibody detecting CCL8 in IHC (p) and ELISA (Capture). Suitable for Mouse and Rat.

Quick Overview for CCL8 antibody (AA 24-97) (ABIN6654185)

Target: CCL8 (Chemokine (C-C Motif) Ligand 8 (CCL8))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL8 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA (Capture)

Product Details anti-CCL8 Antibody

Binding Specificity: AA 24-97

Purification: Antigen affinity purified

Immunogen: Amino acids G24-P97 from the mouse protein were used as the immunogen for the Mcp2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Mcp2 antibody should be determined by the researcher.\. IHC (FFPE): 1-2 μg/mL,ELISA (Capture): 1-5 μg/mL (recombinant mouse protein)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Mcp2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CCL8

Target: CCL8 (Chemokine (C-C Motif) Ligand 8 (CCL8))

Alternative Name: Mcp2 / Ccl8

Background: CCL8, also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene. It is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.

UniProt: Q9Z121