Cathepsin K antibody (AA 163-274)

Catalog No. ABIN6654326

This anti-Cathepsin K antibody is a Mouse Monoclonal antibody detecting Cathepsin K in IHC (p). Suitable for Human.

Quick Overview for Cathepsin K antibody (AA 163-274) (ABIN6654326)

Target: Cathepsin K (CTSK)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin K antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CTSK-2791

Product Details anti-Cathepsin K Antibody

Binding Specificity: AA 163-274

Purification: Purified

Purity: Protein G affinity chromatography

Immunogen: A portion of amino acids 163-274 from the human protein was used as the immunogen for the Cathepsin K antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cathepsin K antibody to be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Cathepsin K antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: Cathepsin K / CTSK

Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades