Pituitary Growth Hormone 20kDa (AA 58-187) antibody

Catalog No. ABIN6654367

The Mouse Monoclonal anti- antibody has been validated for IHC (p). It is suitable to detect in samples from Human.

Quick Overview for Pituitary Growth Hormone 20kDa (AA 58-187) antibody (ABIN6654367)

Target: Pituitary Growth Hormone 20kDa

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RGH-1450

Product Details

Binding Specificity: AA 58-187

Purification: Purified

Purity: Protein G affinity chromatography

Immunogen: A human partial recombinant protein corresponding to amino acids 58-187 was used as the immunogen for this recombinant GH antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant GH antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant GH antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details

Target: Pituitary Growth Hormone 20kDa

Alternative Name: Growth Hormone (pituitary)

Background: Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).