Elastin antibody

Catalog No. ABIN6654574

The Rabbit Monoclonal anti-Elastin antibody has been validated for IHC (p). It is suitable to detect Elastin in samples from Human.

Quick Overview for Elastin antibody (ABIN6654574)

Target: Elastin (ELN)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Elastin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ELN-3131R

Product Details anti-Elastin Antibody

Purification: Purified

Purity: Protein A affinity chromatography

Immunogen: Recombinant full length human protein was used as the immunogen for the recombinant Elastin antibody.

Isotype: IgG kappa

Application Details

Application Notes: Titering of the recombinant Elastin antibody may be required for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant Elastin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for Elastin

Target: Elastin (ELN)

Alternative Name: Elastin

Background: Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries. It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticity to the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension.

Pathways: Regulation of Actin Filament Polymerization