DC-SIGN/CD209 antibody

Catalog No. ABIN6654643

The Rabbit Monoclonal anti-DC-SIGN/CD209 antibody has been validated for IHC (p). It is suitable to detect DC-SIGN/CD209 in samples from Human.

Quick Overview for DC-SIGN/CD209 antibody (ABIN6654643)

Target: DC-SIGN/CD209 (CD209) (CD209)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This DC-SIGN/CD209 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: C209-2749R

Product Details anti-DC-SIGN/CD209 Antibody

Purification: Purified

Purity: Protein A affinity chromatography

Immunogen: Recombinant human protein was used as the immunogen for the DC-SIGN antibody.

Isotype: IgG kappa

Application Details

Application Notes: Optimal dilution of the DC-SIGN antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the DC-SIGN antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for DC-SIGN/CD209

Target: DC-SIGN/CD209 (CD209) (CD209)

Alternative Name: DC-SIGN / CD209

Background: DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.