BMI1 antibody (AA 142-326)

Catalog No. ABIN6654676

The Mouse Monoclonal anti-BMI1 antibody has been validated for IHC (p). It is suitable to detect BMI1 in samples from Human.

Quick Overview for BMI1 antibody (AA 142-326) (ABIN6654676)

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BMI1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BMI1-2689

Product Details anti-BMI1 Antibody

Binding Specificity: AA 142-326

Purification: Purified

Purity: Protein G affinity chromatography

Immunogen: A portion of amino acids 142-326 from the human protein was used as the immunogen for the BMI1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the BMI1 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the BMI1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for BMI1

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Alternative Name: BMI1

Background: The B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) is a transcriptional receptor of the polycomb gene family involved in several cellular processes including cell-cycle regulation, apoptosis, and maintenance of adult and neoplastic stem cells by providing self-renewal capacity. Further, Bmi-1 expression has been associated with malignant transformation, tumor progression, metastatic disease, and poor prognosis in human malignancies.

Pathways: Cell Division Cycle, Autophagy