ODC1 antibody

Catalog No. ABIN6654937

The Rabbit Monoclonal anti-ODC1 antibody has been validated for IHC (p). It is suitable to detect ODC1 in samples from Human.

Quick Overview for ODC1 antibody (ABIN6654937)

Target: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ODC1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ODC1-2878R

Product Details anti-ODC1 Antibody

Purification: Purified

Purity: Protein A affinity chromatography

Immunogen: Recombinant human protein was used as the immunogen for the recombinant ODC1 antibody.

Isotype: IgG kappa

Application Details

Application Notes: Optimal dilution of the recombinant ODC1 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.25-0.5 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant ODC1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for ODC1

Target: ODC1 (Ornithine Decarboxylase 1 (ODC1))

Alternative Name: Ornithine Decarboxylase / ODC1

Background: Recognizes a 53 kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.