p63 antibody

Catalog No. ABIN6655001

This anti-p63 antibody is a Mouse Monoclonal antibody detecting p63 in IHC (p). Suitable for Human and Mouse.

Quick Overview for p63 antibody (ABIN6655001)

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This p63 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TP63-11

Product Details anti-p63 Antibody

Purification: Purified

Purity: Protein G affinity chromatography

Immunogen: Full length human recombinant protein was used as the immunogen for the p63 antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the p63 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.25-0.5 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the p63 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Alternative Name: p63 / Tumor protein 63

Background: P63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands, however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90 % . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80 %. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.