PRMT6 antibody

Catalog No. ABIN6655272

Supplier Product No.: 100-401-i04

This Rabbit Polyclonal antibody specifically detects PRMT6 in WB. It exhibits reactivity toward Human.

Quick Overview for PRMT6 antibody (ABIN6655272)

Target: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRMT6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRMT6 Antibody

Supplier Product No.: 100-401-i04

Supplier: Rockland

Purpose: PRMT6 Antibody

Cross-Reactivity (Details): A BLAST analysis was used to suggest cross-reactivity with PRMT6 from human and mouse based on 100 % homology with the immunizing sequence.

Purification: Anti-PRMT6 Antibody is sera.

Immunogen: PRMT6 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to internal amino acids of human PRMT6 protein.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:100-1:1000

Comment:

Anti-PRMT6 is tested for use in WB. Expect a band approximately 42kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

Preservative: 0.05 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for PRMT6

Target: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Alternative Name: PRMT6

Background:

Synonyms: HRMT1L6, Protein arginine N-methyltransferase 6, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6

Background: Anti-PRMT6 Antibody detects human PRMT6. Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine N-methyltransferase (PRMT) family members. PRMT6 cDNA codes for a protein of approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type I PRMT activity, capable of forming both >NG-monomethylarginine and asymmetric >NG,NG-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activit. GFP-fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus. Anti-PRM6 is ideal for researchers interested in NFkappaB research.

Gene Name: PRMT6

Gene ID: 55170

NCBI Accession: NP_060607

UniProt: Q96LA8