CXCR2 antibody (Internal Region)

Catalog No. ABIN6655456

Supplier Product No.: 600-401-p54

The Rabbit Polyclonal anti-CXCR2 antibody has been validated for WB. It is suitable to detect CXCR2 in samples from Human.

Quick Overview for CXCR2 antibody (Internal Region) (ABIN6655456)

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CXCR2 Antibody

Binding Specificity: Internal Region

Supplier Product No.: 600-401-p54

Supplier: Rockland

Purpose: CXCR2 Antibody

Cross-Reactivity (Details): Anti-CXCR2 antibody is directed against human CXCR2 protein.

Purification: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: CXCR2 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human CXCR2.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 0.5 μg/mL

Comment:

Anti-CXCR2 is tested for Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~40.8 kDa corresponding to the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution:

Reconstitution_Buffer: Restore with deionized water (or equivalent)

Reconstitution_Volume: 100 μL

Buffer:

Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide

Stabilizer: 5 mg BSA

Preservative: 0.05 mg Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at 4° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Alternative Name: CXCR2

Background:

Synonyms: CDw128b,GRO/MGSA receptor,High affinity interleukin-8 receptor B,

Background: CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries. This antibody is suitable for researchers interested in cell signaling research.

Gene Name: CXCR2

Gene ID: 3579

NCBI Accession: NP_001161770

UniProt: P25025

Pathways: cAMP Metabolic Process