COBRA1 antibody

Catalog No. ABIN6657338

Supplier Product No.: 200-301-d18

This anti-COBRA1 antibody is a Mouse Monoclonal antibody detecting COBRA1 in WB and ELISA. Suitable for Human.

Quick Overview for COBRA1 antibody (ABIN6657338)

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COBRA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: F7E4

Product Details anti-COBRA1 Antibody

Supplier Product No.: 200-301-d18

Supplier: Rockland

Purpose: COBRA 1 Antibody

Cross-Reactivity (Details): This antibody is directed against human COBRA 1.

Purification: Anti-COBRA 1 antibody was Protein G purified from culture supernatant.

Immunogen: Anti-COBRA1 Monoclonal Antibody was produced in mouse by repeated immunizations with recombinant full length human COBRA1 purified from E.coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Comment:

Anti-COBRA 1 antibody has been tested by ELISA and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 62 kDa in size corresponding to COBRA1 proteins in neonatal rat brain lysate or other appropriate lysates.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for COBRA1

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Alternative Name: COBRA 1

Background:

Synonyms: COBRA1, Negative elongation factor B, NELF-B, Cofactor of BRCA1

Background: COBRA 1 antibody reacts with COBRA1 (cofactor of BRCA1) also known as NELF-B, which is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription. COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogeneis. Anti-COBRA 1 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: COBRA1

Gene ID: 25920

UniProt: Q8WX92