Retinoic Acid Receptor alpha antibody (N-Term)

Catalog No. ABIN6657357

Supplier Product No.: 209-301-e25

This Mouse Monoclonal antibody specifically detects Retinoic Acid Receptor alpha in WB. It exhibits reactivity toward Human.

Quick Overview for Retinoic Acid Receptor alpha antibody (N-Term) (ABIN6657357)

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoic Acid Receptor alpha antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 763

Product Details anti-Retinoic Acid Receptor alpha Antibody

Binding Specificity: N-Term

Supplier Product No.: 209-301-e25

Supplier: Rockland

Purpose: Retinoic Acid Receptor alpha Antibody

Cross-Reactivity (Details): Retinoic Acid Receptor alpha antibody was Protein G purified from cell culture supernatant.

Purification: Anti-Retinoic Acid Receptor alpha antibody detects Retinoic Acid Receptor alpha.

Immunogen: Anti-Retinoic Acid Receptor alpha was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues from the N-terminal region of RAR-alpha.

Isotype: IgG1

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-Retinoic Acid Receptor alpha antibody is tested for use in Western Blotting to detect a single band at approximately 48 kDa corresponding to expected molecular weight for RAR-α proteins in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for Retinoic Acid Receptor alpha

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Alternative Name: Retinoic Acid Receptor alpha

Background:

Synonyms: mouse anti-Retinoic Acid Receptor alpha Antibody, mouse anti-RAR-alpha antibody, RAR-alpha, Nuclear receptor subfamily 1 group B member 1, NR1B1, Retinoic Acid Receptor, α-Isotype

Background: Retinoic Acid Receptor alpha antibody detects RAR alpha. Retinoic acid (RA, active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

Gene Name: RARA

Gene ID: 5914

UniProt: P10276

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins