Peripherin antibody

Catalog No. ABIN6658099

Supplier Product No.: 212-901-e11

The Chicken Polyclonal anti-Peripherin antibody has been validated for WB, IF and FM. It is suitable to detect Peripherin in samples from Rat.

Quick Overview for Peripherin antibody (ABIN6658099)

Target: Peripherin (PRPH)

Reactivity: Rat

Host: Chicken

Clonality: Polyclonal

Conjugate: This Peripherin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Fluorescence Microscopy (FM)

Product Details anti-Peripherin Antibody

Supplier Product No.: 212-901-e11

Supplier: Rockland

Purpose: Peripherin Antibody

Cross-Reactivity (Details): Anti-Peripherin antibody is directed against rat Peripherin.

Purification: This antibody is a total IgY fraction.

Immunogen: Anti-Peripherin Antibody was produced by repeated immunizations with a recombinant rat peripherin expressed in E. coli.

Isotype: IgG

Application Details

Application Notes:

IF_Microscopy_Dilution: 1:500

Western_Blot_Dilution: 1:1000

Other: User Optimized

Comment:

Anti-Peripherin Antibody is tested for use in Western Blotting and IF. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 57 kDa in size corresponding to peripherin proteins in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Optional[Buffer]: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 ,0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for Peripherin

Target: Peripherin (PRPH)

Alternative Name: Peripherin

Background:

Synonyms: NEF4, PRPH1, Nervous system antibodies, Peripherin, prph, prph1 antibody, monoclonal anti-peripherin, anti-peripherin antibody produced in chicken, chicken anti-peripherin antibody

Background: Peripherin Antibody detects Peripherin. Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. Anti-Peripherin Antibody is ideal for investigators involved in Neuroscience and Cancer research

Gene Name: PRPH

Gene ID: 3414

UniProt: P21807