SYN1 antibody (pSer603)

Catalog No. ABIN6658200

Supplier Product No.: 612-401-c95

This Rabbit Polyclonal antibody specifically detects SYN1 in WB. It exhibits reactivity toward Rat and has been mentioned in 2+ publications.

Quick Overview for SYN1 antibody (pSer603) (ABIN6658200)

Target: SYN1 (Synapsin I (SYN1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SYN1 Antibody

Binding Specificity: pSer603

Supplier Product No.: 612-401-c95

Supplier: Rockland

Purpose: Synapsin I phospho S603 Antibody

Cross-Reactivity (Details): The antibody detects Synapsin I that is phosphorylated at S603.

Purification: Anti-Synapsin I pS603 antibody is directed against bovine Synapsin I.

Immunogen: Anti-Synapsin I pS603 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser603 of Synapsin I.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-Synapsin I pS603 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 78 kDa in size corresponding to synapsin I doublet protein phosphorylated at Ser603.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

References for anti-SYN1 antibody (ABIN6658200)

Engholm-Keller, Waardenberg, Müller, Wark, Fernando, Arthur, Robinson, Dietrich, Schoch, Graham: "The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation." in: PLoS biology, Vol. 17, Issue 3, pp. e3000170, (2019) (PubMed).

Hammond, Lu, Gelbard: "Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation." in: Frontiers in cellular neuroscience, Vol. 9, pp. 505, (2016) (PubMed).

Target Details for SYN1

Target: SYN1 (Synapsin I (SYN1))

Alternative Name: Synapsin I

Background:

Synonyms: Synapsin I, SYN1

Background: Synapsin I pS603 antibody is directed against rat Synapsin I, whcih plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases. Phosphorylation of this site is thought to regulate synaptic vesicle function. Anti-Synapsin I pS603 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: SYN1

Gene ID: 24949

NCBI Accession: NP_001104252

UniProt: P09951