APP antibody (C-Term)

Catalog No. ABIN6658203

Supplier Product No.: 612-401-253

This Rabbit Polyclonal antibody specifically detects APP in WB and ELISA. It exhibits reactivity toward Rat.

Quick Overview for APP antibody (C-Term) (ABIN6658203)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-APP Antibody

Binding Specificity: C-Term

Supplier Product No.: 612-401-253

Supplier: Rockland

Purpose: Beta Amyloid Antibody

Cross-Reactivity (Details): The antibody is directed against rat Beta Amyloid.

Purification: Anti-Beta Amyloid Antibody is directed against rat Beta Amyloid proteins.

Immunogen: Anti-Beta Amyloid Antibody was produced by repeated immunizations with synthetic peptide corresponding to amino acid residues from the C-terminal region.

Isotype: IgG

Application Details

Application Notes:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Comment:

Anti-Beta Amyloid antibody is tested for use in ELISA, Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 115 kDa in size corresponding to the APP protein in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: APP

Background:

Synonyms: Amyloid beta A4 protein, ABPP, Alzheimer disease amyloid A4 protein homolog, Amyloidogenic glycoprotein, A-beta, ABeta antibody

Background: Anti-Beta Amyloid antibody recognizes beta amyloid protein also called amyloid precursor protein (APP). A large body of evidence has implicated the APP in the pathogenesis of Alzheimer's disease (AD). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD. Anti-Beta Amyloid antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: APP

Gene ID: 54226

NCBI Accession: NP_062161

UniProt: P08592

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour