GABRA6 antibody

Catalog No. ABIN6658222

Supplier Product No.: 100-401-d48

The Rabbit Polyclonal anti-GABRA6 antibody has been validated for WB. It is suitable to detect GABRA6 in samples from Rat.

Quick Overview for GABRA6 antibody (ABIN6658222)

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRA6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GABRA6 Antibody

Supplier Product No.: 100-401-d48

Supplier: Rockland

Purpose: GABAA Receptor alpha 6 Antibody

Cross-Reactivity (Details): Anti-GABA(A) Receptor alpha 6 Antibody is directed against rat GABA(A) Receptor alpha 6.

Purification: The antibody was prepared from monospecific neat serum.

Immunogen: Anti-GABA(A) Receptor a 6 Antibody was produced by repeated immunizations with rat GABA(A) receptor alpha 6- Synthetic peptide corresponding to amino acid specific to the alpha 6 subunit.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-GABA(A) Receptor alpha 6 (Rabbit) antibody has been tested in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 57 kDa in size corresponding to the alpha 6 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for GABRA6

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Alternative Name: GABA(A) Receptor alpha 6

Background:

Synonyms: Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6

Background: Anti-GABA(A) Receptor alpha 6 Antibody detects GABA(A) Receptor alpha 6. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Phosphorylation of β-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) receptor alpha 6 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRA6

Gene ID: 29708

NCBI Accession: NP_068613

UniProt: P30191

Pathways: Synaptic Membrane