GABRA6 antibody (Cytoplasmic Loop)

Catalog No. ABIN6658223

Supplier Product No.: 600-401-d48

This anti-GABRA6 antibody is a Rabbit Polyclonal antibody detecting GABRA6 in WB. Suitable for Rat.

Quick Overview for GABRA6 antibody (Cytoplasmic Loop) (ABIN6658223)

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRA6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GABRA6 Antibody

Binding Specificity: Cytoplasmic Loop

Supplier Product No.: 600-401-d48

Supplier: Rockland

Purpose: GABA(A) Receptor alpha 6 Antibody

Cross-Reactivity (Details): Anti-GABA(A) Receptor alpha 6 Antibody is directed against rat GABA(A) Receptor alpha 6.

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GABA(A) Receptor alpha 6 Antibody was produced in rabbit by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the alpha 6 subunit.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-GABA(A) Receptor alpha 6 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 57 kDa in size corresponding to the alpha 6 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for GABRA6

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Alternative Name: GABA(A) Receptor alpha 6

Background:

Synonyms: Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6

Background: Anti-GABA(A) Receptor alpha 6 Antibody detects GABA(A) Receptor alpha 6. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor alpha 6 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRA6

Gene ID: 29708

NCBI Accession: NP_068613

UniProt: P30191

Pathways: Synaptic Membrane