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GABRG2 antibody

This Rabbit Polyclonal antibody specifically detects GABRG2 in WB and IHC. It exhibits reactivity toward Rat.
Rockland
Catalog No. ABIN6658275
Supplier Product No.: 112-401-c81

Quick Overview for GABRG2 antibody (ABIN6658275)

Target

See all GABRG2 Antibodies
GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Reactivity

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Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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  • 1
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  • 1
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  • 1
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  • 1
This GABRG2 antibody is un-conjugated

Application

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Western Blotting (WB), Immunohistochemistry (IHC)
  • Supplier Product No.

    112-401-c81

    Supplier

    Rockland

    Purpose

    GABA(A) Receptor gamma 2 Antibody

    Cross-Reactivity (Details)

    Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2.

    Purification

    The antibody was prepared from monospecific neat serum.

    Immunogen

    Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with rat GABA(A) Receptor gamma 2- Synthetic peptide corresponding to amino acid residues specific to the gamma 2 subunit.

    Isotype

    IgG
  • Application Notes

    Immunohistochemistry_Dilution: 1:400

    Western_Blot_Dilution: 1:1000

    Comment

    Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody has been tested in Western Blotting and IHC. Expect a band of approximately 46kDa in size corresponding γ2-subunit of the GABAA receptor in Western blots of rat brain extracts. Specific conditions should by optimized by the end user.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Storage

    4 °C,-20 °C

    Storage Comment

    Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

    Expiry Date

    12 months
  • Target

    GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

    Alternative Name

    GABA(A) Receptor gamma 2

    Background

    Synonyms: rabbit anti-GABA(A) Receptor gamma 2 Antibody, Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2

    Background: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) sub-type. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Phosphorylation of β-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) Receptor gamma 2 antibody is ideal for investigators involved in Neuroscience.

    Gene Name: GABRG2

    Gene ID

    29709

    NCBI Accession

    NP_899156
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