MOG antibody (PE-Cy7)

Catalog No. ABIN668494

This Rabbit Polyclonal antibody specifically detects MOG in FACS. It exhibits reactivity toward Human, Mouse, Rat, Pig and Guinea Pig.

Quick Overview for MOG antibody (PE-Cy7) (ABIN668494)

Target: MOG (Myelin Oligodendrocyte Glycoprotein (MOG))

Reactivity: Human, Mouse, Rat, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MOG antibody is conjugated to PE-Cy7

Application: Flow Cytometry (FACS)

Product Details anti-MOG Antibody (PE-Cy7)

Specificity: Excitation / Emission Wavelengths: 480,565,743nm/767nm

Cross-Reactivity: Rat (Rattus), Pig (Porcine), Guinea Pig

Purification: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human MOG

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Comment:

Excitation / Emission wavelength: 496,565nm / 774nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % Gentamicin.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4 °C for 12 months

Expiry Date: 12 months

Target Details for MOG

Target: MOG (Myelin Oligodendrocyte Glycoprotein (MOG))

Alternative Name: MOG

Background: Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.

Molecular Weight: 28kDa

Gene ID: 4340