WNK4 antibody (AA 351-450) (HRP)

Catalog No. ABIN668535

This anti-WNK4 antibody is a Rabbit Polyclonal antibody detecting WNK4 in ELISA, WB. Suitable for Mouse.

Quick Overview for WNK4 antibody (AA 351-450) (HRP) (ABIN668535)

Target: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WNK4 antibody is conjugated to HRP

Application: ELISA, Western Blotting (WB)

Product Details anti-WNK4 Antibody (HRP)

Binding Specificity: AA 351-450

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human WNK4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for WNK4

Target: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Alternative Name: WNK4

Background:

Synonyms: PHA 2B, PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN.

Background: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.

Gene ID: 65266