Adiponectin Receptor 1 antibody (AA 241-270)

Catalog No. ABIN670836

This anti-Adiponectin Receptor 1 antibody is a Rabbit Polyclonal antibody detecting Adiponectin Receptor 1 in WB, ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). Suitable for Human, Mouse and Rat. This Primary Antibody has been cited in 12+ publications.

Quick Overview for Adiponectin Receptor 1 antibody (AA 241-270) (ABIN670836)

Target: Adiponectin Receptor 1 (ADIPOR1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adiponectin Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Adiponectin Receptor 1 Antibody

Binding Specificity: AA 241-270

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Adiponectin Receptor 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Adiponectin Receptor 1 antibody (ABIN670836)

Wang, Gao, Lau, Wang, Liu, Li, Wang, Yuan, Koch, Ma: "G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart." in: Circulation, Vol. 131, Issue 16, pp. 1392-404, (2015) (PubMed).

Wu, Chio, Tsai, Chang, Lin, Huang, Lin: "Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis." in: Molecular neurobiology, (2015) (PubMed).

Cao, Li, Luo, Li, Liu, Gao, Yin, Luan: "Molecular cloning and expression analysis of adiponectin and its receptors (AdipoR1 and AdipoR2) in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle." in: Reproductive biology and endocrinology : RB&E, Vol. 13, pp. 87, (2015) (PubMed).

Liu, Liang, Lau, Wang, Zhao, Li, Wang, Yuan, Lopez, Christopher, Xiao, Ma, Wang: "High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation." in: Free radical biology & medicine, Vol. 89, pp. 473-485, (2015) (PubMed).

Guo, Qi, Yu, Du, Wu, Liu: "Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats." in: Diabetology & metabolic syndrome, Vol. 6, Issue 1, pp. 29, (2014) (PubMed).

Morad, Abrahamsson, Dabrosin: "Estradiol affects extracellular leptin:adiponectin ratio in human breast tissue in vivo." in: The Journal of clinical endocrinology and metabolism, Vol. 99, Issue 9, pp. 3460-7, (2014) (PubMed).

Ji, Wu, Ma, Ma, Qin: "The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy." in: Molecular biology reports, Vol. 41, Issue 4, pp. 2151-9, (2014) (PubMed).

Li, Su, Zong: "Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy." in: Experimental and therapeutic medicine, Vol. 7, Issue 4, pp. 1023-1027, (2014) (PubMed).

Guo, Qin, Zhang, Li, Yin: "Effect of rosiglitazone on the expression of cardiac adiponectin receptors and NADPH oxidase in type 2 diabetic rats." in: European journal of pharmacology, Vol. 685, Issue 1-3, pp. 116-25, (2012) (PubMed).

Guo, Zhang, Li, Xu: "Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats." in: Cardiovascular diabetology, Vol. 11, pp. 94, (2012) (PubMed).

Liu, Wu, Zhang, Chen, Liu, Wu, Zhu: "The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats." in: European journal of pharmacology, Vol. 650, Issue 1, pp. 384-9, (2010) (PubMed).

Target Details for Adiponectin Receptor 1

Target: Adiponectin Receptor 1 (ADIPOR1)

Alternative Name: Adiponectin Receptor 1

Background:

Synonyms: CGI45, PAQR1, ACDCR1, CGI-45, TESBP1A, Adiponectin receptor protein 1, Progestin and adipoQ receptor family member I, ADIPOR1

Background: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.

Gene ID: 51094

UniProt: Q96A54

Pathways: AMPK Signaling