SLK antibody (AA 1-232) (DyLight 550)

Catalog No. ABIN7354653

This anti-SLK antibody is a Rabbit Polyclonal antibody detecting SLK in FACS. Suitable for Human.

Quick Overview for SLK antibody (AA 1-232) (DyLight 550) (ABIN7354653)

Target: SLK (STE20-Like Kinase (SLK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLK antibody is conjugated to DyLight 550

Application: Flow Cytometry (FACS)

Product Details anti-SLK Antibody (DyLight 550)

Binding Specificity: AA 1-232

Purpose: Anti-Human SLK DyLight® 550 conjugated Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human SLK DyLight® 550 conjugated Antibody -Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human SLK recombinant protein (Position: M1-E232).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. "Entrez Gene: SLK STE20-like kinase (yeast)". 2. Sabourin, L. A., Tamai, K., Seale, P., Wagner, J., Rudnicki, M. A. Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region. Molec. Cell. Biol. 20: 684-696, 2000. Note: Erratum: Molec. Cell. Biol. 20: 2949, 2000. 3. Zhapparova, O. N., Fokin, A. I., Vorobyeva, N. E., Bryantseva, S. A., Nadezhdina, E. S. Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome. Molec. Biol. Cell 24: 3205-3214, 2013. [

Comment:

Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for SLK

Target: SLK (STE20-Like Kinase (SLK))

Alternative Name: SLK

Background:

Synonyms: STE20-like serine/threonine-protein kinase, STE20-like kinase, hSLK, CTCL tumor antigen se20-9, STE20-related serine/threonine-protein kinase, STE20-related kinase, Serine/threonine-protein kinase 2, SLK, KIAA0204, STK2

Tissue Specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.

Background: STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene. This gene is mapped to chromosome 10q24.33-q25.1. SLK is a kinase with multiple functional domains that is predicted to regulate cytoskeletal organization and responses to apoptotic stimuli.

Molecular Weight: 39 kDa

Gene ID: 9748

UniProt: Q9H2G2