NOTCH3 antibody (APC)

Catalog No. ABIN6722240

The Mouse Monoclonal anti-NOTCH3 antibody has been validated for FACS. It is suitable to detect NOTCH3 in samples from Human.

Quick Overview for NOTCH3 antibody (APC) (ABIN6722240)

Target: NOTCH3 (Notch 3 (NOTCH3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOTCH3 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: MHN3-21

Product Details anti-NOTCH3 Antibody (APC)

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Target Details for NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Alternative Name: Notch3

Background:

Synonyms: NOTCH3,Notch 3,Notch 3 extracellular truncation,Notch 3 intracellular domain

Background: The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.

Gene ID: 4854

UniProt: Q9UM47

Pathways: Notch Signaling