CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C) (PE-Cy5)

Details for Product anti-PTPRC Antibody No. ABIN6727492
Antigen
  • PTPRC
  • si:dkeyp-47c5.1
  • B220
  • CD45
  • CD45R
  • GP180
  • L-CA
  • LCA
  • LY5
  • T200
  • Cd45
  • Ly-5
  • Lyt-4
  • loc
  • Lca
  • RT7
  • cd45
  • protein tyrosine phosphatase, receptor type C
  • protein tyrosine phosphatase, receptor type, C
  • receptor-type tyrosine-protein phosphatase C
  • PTPRC
  • ptprc
  • LOC100074271
  • Ptprc
Reactivity
Mouse (Murine)
1275
555
143
82
52
40
36
29
19
14
13
13
9
8
7
4
4
3
3
2
1
1
1
1
Host
Rat
1195
539
287
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD45 antibody is conjugated to PE-Cy5
238
214
137
129
52
25
24
23
23
23
22
21
17
15
14
11
11
10
10
10
9
8
8
7
7
7
7
7
7
7
7
7
7
7
7
7
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5
5
5
5
5
5
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4
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
1671
634
450
398
322
265
207
111
76
74
52
36
32
16
8
4
4
3
3
3
3
2
2
2
1
1
Options
Clone 30-F11
Isotype IgG2b, kappa
Plasmids, Primers & others Plasmids, Primers & others CD45 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD45 (PTPRC Antibody Abstract)
Background

Synonyms: Receptor-type tyrosine-protein phosphatase C,Ptprc,L-CA,Ly-5,T200,CD45

Background: CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from alternative splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Gene ID 19264
UniProt P06800
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.05 % Proclin300, 1 % BSA
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
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