CD45 antibody (Protein tyrosine Phosphatase, Receptor Type, C) (PE-Cy5)

Details for Product anti-PTPRC Antibody No. ABIN6727493
Target
Reactivity
Mouse
525
272
67
43
27
25
22
12
11
9
9
6
6
5
4
4
3
2
2
1
1
1
1
1
Host
Rat
424
245
199
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD45 antibody is conjugated to PE-Cy5
86
75
73
53
19
17
17
16
15
13
11
11
11
9
8
8
8
8
7
7
6
6
6
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
729
277
213
189
172
117
105
74
52
50
28
28
27
6
4
4
4
3
3
2
2
2
2
1
1
1
Options
Clone 30-F11
Isotype IgG2b, kappa
Target
Alternative Name CD45 (PTPRC Antibody Abstract)
Background

Synonyms: Receptor-type tyrosine-protein phosphatase C,Ptprc,L-CA,Ly-5,T200,CD45

Background: CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from alternative splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Gene ID 19264
UniProt P06800
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.05 % Proclin300, 1 % BSA
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.