CYR61 antibody (AA 251-379) (Biotin)

Catalog No. ABIN674501

The Rabbit Polyclonal anti-CYR61 antibody has been validated for WB and ELISA. It is suitable to detect CYR61 in samples from Human.

Quick Overview for CYR61 antibody (AA 251-379) (Biotin) (ABIN674501)

Target: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYR61 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA

Product Details anti-CYR61 Antibody (Biotin)

Binding Specificity: AA 251-379

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Cyr61

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CYR61

Target: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))

Alternative Name: Cyr61

Background:

Synonyms: CCN1, GIG1, IGFBP10, Protein CYR61, CCN family member 1, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10, IBP-10, IGF-binding protein 10, IGFBP-10, Protein GIG1, CYR61

Background: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene ID: 3491

UniProt: O00622

Pathways: Positive Regulation of Endopeptidase Activity, Growth Factor Binding