SERPINC1 antibody (C-Term)

Catalog No. ABIN6746198

This Rabbit Polyclonal antibody specifically detects SERPINC1 in WB. It exhibits reactivity toward Human, Mouse, Dog, Horse and Monkey and has been mentioned in 4+ publications.

Quick Overview for SERPINC1 antibody (C-Term) (ABIN6746198)

Target: SERPINC1 (Serpin Family C Member 1 (SERPINC1))

Reactivity: Human, Mouse, Dog, Horse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SERPINC1 Antibody

Binding Specificity: C-Term

Specificity: Mouse SERPINC1 / Antithrombin-III

Predicted Reactivity: Percent identity by BLAST analysis: Human, Mouse, Dog, Horse (100%) Rat, Bovine, Rabbit, Pig, Guinea pig (92%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide from C-Terminus of mouse Serpinc1 (P32261, NP_543120). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Elephant, Dog, Horse, Opossum (100%), Rat, Sheep, Panda, Bovine, Bat, Rabbit, Pig, Guinea pig, Platypus (92%), Xenopus (84%), Turkey (83%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: WB (1 μg/mL)

Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS with 2 % sucrose

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.

References for anti-SERPINC1 antibody (ABIN6746198)

Cool, Normant, Shen, Chen, Pannell, Zhang, Loh: "Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice." in: Cell, Vol. 88, Issue 1, pp. 73-83, (1997) (PubMed).

Shen, Loh: "Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 10, pp. 5314-9, (1997) (PubMed).

Varlamov, Fricker: "The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing." in: The Journal of biological chemistry, Vol. 271, Issue 11, pp. 6077-83, (1996) (PubMed).

Manser, Fernandez, Loo, Goh, Monfries, Hall, Lim: "Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro." in: The Biochemical journal, Vol. 267, Issue 2, pp. 517-25, (1990) (PubMed).

Target Details for SERPINC1

Target: SERPINC1 (Serpin Family C Member 1 (SERPINC1))

Alternative Name: SERPINC1 / Antithrombin III

Background: Name/Gene ID: SERPINC1

Synonyms: SERPINC1, Antithrombin III, Antithrombin-III, ATIII, AT3, Serpin C1, AT3D, THPH7

Gene ID: 462

NCBI Accession: NP_543120

UniProt: P01008