CCL2 antibody

Catalog No. ABIN675863

The Rabbit Polyclonal anti-CCL2 antibody has been validated for WB, IHC (p) and IF (p). It is suitable to detect CCL2 in samples from Human, Mouse, Rat, Dog, Pig and Cow. There are 3+ publications available.

Quick Overview for CCL2 antibody (ABIN675863)

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CCL2 Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CCL2

Isotype: IgG

Application Details

Application Notes: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

References for anti-CCL2 antibody (ABIN675863)

Heilmann, Schinke, Bindl, Wehner, Rapp, Haffner-Luntzer, Nemitz, Liedert, Amling, Ignatius: "The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing." in: PLoS ONE, Vol. 8, Issue 12, pp. e84232, (2014) (PubMed).

Su, Min, Cao, Yan, Zhao, Li, Chai, Mei, Yang, Zhang, Zhang, Liu, Sun, Che, Yang: "LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria." in: Nature communications, Vol. 5, pp. 4434, (2014) (PubMed).

Kong, Luo, Li, Zhou, He: "The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits." in: Lipids in health and disease, Vol. 12, pp. 115, (2013) (PubMed).

Target Details for CCL2

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Alternative Name: MCP1/CCL2

Background:

Synonyms: C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2, CCL2, CCL-2, MCP1, SCYA2

Background: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Molecular Weight: 11kDa

Gene ID: 6347

UniProt: P13500

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, The Global Phosphorylation Landscape of SARS-CoV-2 Infection