Caldesmon antibody (pSer789) (FITC)

Catalog No. ABIN677340

This anti-Caldesmon antibody is a Rabbit Polyclonal antibody detecting Caldesmon in WB, IF (cc) and IF (p). Suitable for Rat and Mouse.

Quick Overview for Caldesmon antibody (pSer789) (FITC) (ABIN677340)

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caldesmon antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Caldesmon Antibody (FITC)

Binding Specificity: pSer789

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Caldesmon around the phosphorylation site of Ser789

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Caldesmon

Target: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Alternative Name: Caldesmon

Background:

Synonyms: Caldesmon S789, Caldesmon Ser789, p-Caldesmon S789, p-Caldesmon Ser789, p-Caldesmon Ser789, CAD, CALD 1, CALD1, CALD1_HUMAN, Caldesmon 1, Caldesmon 1 Isoform 1, Caldesmon 1 Isoform 2, Caldesmon 1 Isoform 3, Caldesmon 1 Isoform 4, Caldesmon 1 Isoform 5, Caldesmon, Caldesmon1, CDM, H CAD, HCAD, L CAD, LCAD, MGC21352, NAG22.

Background: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jul 2008].

Gene ID: 800

Pathways: Myometrial Relaxation and Contraction