GRM2/4 antibody (AA 31-130) (Cy5)

Catalog No. ABIN677922

This anti-GRM2/4 antibody is a Rabbit Polyclonal antibody detecting GRM2/4 in WB, IF (cc) and IF (p). Suitable for Human.

Quick Overview for GRM2/4 antibody (AA 31-130) (Cy5) (ABIN677922)

Target: GRM2/4 (Glutamate Receptor, Metabotropic 2/4 (GRM2/4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM2/4 antibody is conjugated to Cy5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GRM2/4 Antibody (Cy5)

Binding Specificity: AA 31-130

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GRM2+GRM4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GRM2/4

Target: GRM2/4 (Glutamate Receptor, Metabotropic 2/4 (GRM2/4))

Sub Type: Cocktail

Background:

Synonyms: NULL

Background: L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Gene ID: 2912