TRPM2 antibody (AA 951-1050)

Catalog No. ABIN681223

Product Details anti-TRPM2 Antibody

Target: TRPM2 (Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2))

Binding Specificity: AA 951-1050

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TRPM2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TRPM2

Target: TRPM2 (Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2))

Alternative Name: TRPM2 (TRPM2 Products)

Synonyms: EREG1 antibody, KNP3 antibody, LTRPC2 antibody, NUDT9H antibody, NUDT9L1 antibody, TRPC7 antibody, Trpm2-predicted antibody, TRPM2 antibody, si:ch73-263b18.1 antibody, 9830168K16Rik antibody, C79133 antibody, Trp7 antibody, Trrp7 antibody, transient receptor potential cation channel subfamily M member 2 antibody, transient receptor potential cation channel, subfamily M, member 2 antibody, transient receptor potential cation channel subfamily C member 7 antibody, TRPM2 antibody, Trpm2 antibody, trpm2 antibody, TRPC7 antibody

Background:

Synonyms: KNP3, EREG1, TRPC7, LTRPC2, NUDT9H, NUDT9L1, Transient receptor potential cation channel subfamily M member 2, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, Transient receptor potential channel 7, TRPM2

Background: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.

Gene ID: 7226

UniProt: O94759