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TRPM2 Products

(Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2))

Categories

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008].

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Featured TRPM2 Categories

TRPM2 Antibodies

High quality antibodies with extensive validation data.

Recommended TRPM2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, WB, ELISA, IF
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Cat. No. ABIN7172859
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, WB, ELISA
Validations
  • (3)
Cat. No. ABIN7172857
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, WB, ELISA
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Cat. No. ABIN6265756
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our TRPM2 products

Gattkowski, Johnsen, Bauche, Möckl, Kulow, Garcia Alai, Rutherford, Fliegert, Tidow: "Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2." in: Biochimica et biophysica acta. Molecular cell research, (2018) (PubMed).

Yee, Freestone, Bai, Lipski: "Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone." in: Experimental neurology, Vol. 287, Issue Pt 1, pp. 34-43, (2016) (PubMed).

Chung, Asgar, Lee, Shim, Dumler, Ro: "The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia." in: Neuroscience, Vol. 297, pp. 160-9, (2015) (PubMed).

Rah, Kwak, Chung, Kim: "ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells." in: Scientific reports, Vol. 5, pp. 9482, (2015) (PubMed).

Vaisitti, Audrito, Serra, Buonincontri, Sociali, Mannino, Pagnani, Zucchetto, Tissino, Vitale, Coscia, Usai, Pepper, Gattei, Bruzzone, Deaglio: "The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting." in: Leukemia, Vol. 29, Issue 2, pp. 356-68, (2015) (PubMed).

Roberge, Roussel, Andersson, Meli, Vidal, Blandel, Lanner, Le Guennec, Katz, Westerblad, Lacampagne, Fauconnier: "TNF-α-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes." in: Cardiovascular research, Vol. 103, Issue 1, pp. 90-9, (2014) (PubMed).

Lu, Xiang, Clemmer, Mittwede, Hester: "Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels." in: Microcirculation (New York, N.Y. : 1994), Vol. 21, Issue 8, pp. 754-60, (2014) (PubMed).

Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: "Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists." in: Journal of medicinal chemistry, Vol. 56, Issue 24, pp. 10079-102, (2013) (PubMed).

Melzer, Hicking, Göbel, Wiendl: "TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation." in: PLoS ONE, Vol. 7, Issue 10, pp. e47617, (2012) (PubMed).

Chung, Freestone, Lipski: "Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat." in: Journal of neurophysiology, Vol. 106, Issue 6, pp. 2865-75, (2011) (PubMed).

Synonyms and alternative names related to TRPM2

transient receptor potential cation channel subfamily M member 2 (TRPM2), transient receptor potential cation channel, subfamily M, member 2 (Trpm2), transient receptor potential cation channel, subfamily M, member 2 (trpm2), transient receptor potential cation channel subfamily C member 7 (TRPC7), transient receptor potential cation channel subfamily M member 2 (trpm2), transient receptor potential cation channel subfamily M member 2 (Trpm2), 9830168K16Rik, C79133, EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, si:ch73-263b18.1, Trp7, TRPC7, TRPM2, Trpm2-predicted, Trrp7

Protein level used designations for TRPM2

  • LTrpC-2
  • estrogen-responsive element-associated gene 1 protein
  • long transient receptor potential channel 2
  • transient receptor potential cation channel subfamily M member 2
  • transient receptor potential channel 7
  • transient receptor potential melastatin family 2
  • transient receptor potential cation channel, subfamily M, member 2
  • transient receptor potential cation channel, subfamily C, member 7
  • transient receptor potential cation channel, subfamily C, member 7-like
  • transient receptor potential cation channel subfamily M member 2-like
  • transient receptor protein 7
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